Major Depressive Disorder involves persistent sadness, loss of interest, or lack of motivation that lasts most of the day for at least two weeks or longer. People may feel tired, hopeless, withdrawn, or overwhelmed, and everyday tasks can feel unusually difficult. Depression can also affect sleep, appetite, concentration, and physical wellbeing. With compassionate care and effective treatment, many people experience significant improvement and regain a sense of purpose, connection, and joy.